| Function | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | U3 Small Nucleolar Ribonucleoprotein Protein Mpp10M Phase Phosphoprotein 10 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusChromosomeFibrillar Region Of The NucleolusAfter Dissolution Of The Nucleolus In Early M Phase Becomes Associated With Chromosomes Through Metaphase And AnaphaseIn Telophase Localized To Small Cellular Prenucleolar Bodies That Not Always Contain FibrillarinThe Reassociation With Nucleolus Is Preceeded By The Arrival Of Fibrillarin |
| Alternative Protein Names | U3 Small Nucleolar Ribonucleoprotein Protein Mpp10 proteinM Phase Phosphoprotein 10 proteinMPHOSPH10 proteinMPP10 protein |
Information sourced from Uniprot.org
