| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. |
| Protein Name | Mitochondrial Amidoxime-Reducing Component 1Marc1Molybdenum Cofactor Sulfurase C-Terminal Domain-Containing Protein 1Mosc Domain-Containing Protein 1Moco Sulfurase C-Terminal Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Type Ii Membrane ProteinMembraneLipid-AnchorMitochondrial Import Is Mediated By Aa 1-40 And Requires Atp |
| Alternative ELISA Names | Mitochondrial Amidoxime-Reducing Component 1 ELISA kitMarc1 ELISA kitMolybdenum Cofactor Sulfurase C-Terminal Domain-Containing Protein 1 ELISA kitMosc Domain-Containing Protein 1 ELISA kitMoco Sulfurase C-Terminal Domain-Containing Protein 1 ELISA kitMTARC1 ELISA kitMARC1 ELISA kitMOSC1 ELISA kit |
| output | |
Information sourced from Uniprot.org
