Human MOBKL1A/MOB1B protein (Recombinant) (His-Tag) (STJP018133)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MOBKL1A/MOB1B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MOB1B |
| Gene ID | 92597 |
| Uniprot ID | MOB1B_HUMAN |
| Accession Number | NP_775739 |
| Immunogen | Human |
| Immunogen Region | 1-216aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. |
| Post Translational Modifications | Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. |
| Function | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. |
| Protein Name | Mob Kinase Activator 1bMob1 Homolog 1aMob1aMob1bMps One Binder Kinase Activator-Like 1a |
| Database Links | Reactome: R-HSA-2028269 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Mob Kinase Activator 1b proteinMob1 Homolog 1a proteinMob1a proteinMob1b proteinMps One Binder Kinase Activator-Like 1a proteinMOB1B proteinMOB4A proteinMOBKL1A protein |
Information sourced from Uniprot.org