Human MMP-1 protein (Recombinant) (His-Tag) (STJP018641)

Name: Human MMP-1 protein (Recombinant) (His-Tag) (STJP018641)
SKU: STJP018641
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP018641

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Short Description	Recombinant-Human MMP-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Denatured
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.4M urea
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	MMP1
Gene ID	4312
Uniprot ID	MMP1_HUMAN
Accession Number	NP_002412
Immunogen	Human
Immunogen Region	100-469aa
Immunogen Sequence	FVLTEGN PRWEQTHLTY RIENYTPDLP RADVDHAIEK AFQLWSNVTP LTFTKVSEGQ ADIMISFVRG DHRDNSPFDG PGGNLAHAFQ PGPGIGGDAH FDEDERWTNN FREYNLHRVA AHELGHSLGL SHSTDIGALM YPSYTFSGDV QLAQDDIDGI QAIYGRSQNP VQPIGPQTPK ACDSKLTFDA ITTIRGEVMF FKDRFY

Post Translational Modifications	Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase. Tyrosine phosphorylated in platelets by PKDCC/VLK.
Function	Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Protein Name	Interstitial Collagenase Fibroblast Collagenase Matrix Metalloproteinase-1 Mmp-1 Cleaved Into - 22 Kda Interstitial Collagenase - 27 Kda Interstitial Collagenase
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-1592389 Reactome: R-HSA-210991 Reactome: R-HSA-381426 Reactome: R-HSA-6785807
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Protein Names	Interstitial Collagenase protein Fibroblast Collagenase protein Matrix Metalloproteinase-1 protein Mmp-1 Cleaved Into - 22 Kda Interstitial Collagenase - 27 Kda Interstitial Collagenase protein MMP1 protein CLG protein

Information sourced from Uniprot.org