Human MINCLE/CLEC4E protein (Recombinant) (His-Tag) (STJP019112)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MINCLE/CLEC4E-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC4E |
| Gene ID | 26253 |
| Uniprot ID | CLC4E_HUMAN |
| Accession Number | NP_055173 |
| Immunogen | Human |
| Immunogen Region | 41-219aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in monocytes and macrophages. |
| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue. |
| Protein Name | C-Type Lectin Domain Family 4 Member EC-Type Lectin Superfamily Member 9Macrophage-Inducible C-Type LectinMincle |
| Database Links | Reactome: R-HSA-5621480 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinCell ProjectionPhagocytic Cup |
| Alternative Protein Names | C-Type Lectin Domain Family 4 Member E proteinC-Type Lectin Superfamily Member 9 proteinMacrophage-Inducible C-Type Lectin proteinMincle proteinCLEC4E proteinCLECSF9 proteinMINCLE proteinUNQ218 proteinPRO244 protein |
Information sourced from Uniprot.org