| Function | Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. |
| Protein Name | Mitochondrial Dynamics Protein Mief1Mitochondrial Dynamics Protein Of 51 KdaMitochondrial Elongation Factor 1Smith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-LikeSmcr7-Like Protein |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane Protein |
| Alternative Protein Names | Mitochondrial Dynamics Protein Mief1 proteinMitochondrial Dynamics Protein Of 51 Kda proteinMitochondrial Elongation Factor 1 proteinSmith-Magenis Syndrome Chromosomal Region Candidate Gene 7 Protein-Like proteinSmcr7-Like Protein proteinMIEF1 proteinMID51 proteinSMCR7L protein |
Information sourced from Uniprot.org
