Human MGRN1 protein (Recombinant) (N-His) (STJP007693)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MGRN1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MGRN1 |
| Gene ID | 23295 |
| Uniprot ID | MGRN1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp16-Gln251 |
Additional Info
| Function | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling. |
| Protein Name | E3 Ubiquitin-Protein Ligase Mgrn1Mahogunin Ring Finger Protein 1Ring Finger Protein 156Ring-Type E3 Ubiquitin Transferase Mgrn1 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Early EndosomeThe Endosomal Localization Is Dependent On The Interaction With Tsg101Isoform 1: CytoplasmCytosolNucleusTranslocation From The Cytosol To The Nucleus Is Seen Only In The Presence Of Mc1r And Mc4rBut Not Tbxa2rExcluded From NucleoliIsoform 2: CytoplasmIsoform 3: CytoplasmCell MembraneIsoform 4: Cytoplasm |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Mgrn1 proteinMahogunin Ring Finger Protein 1 proteinRing Finger Protein 156 proteinRing-Type E3 Ubiquitin Transferase Mgrn1 proteinMGRN1 proteinKIAA0544 proteinRNF156 protein |
Information sourced from Uniprot.org