Name: Human MGRN1 protein (Recombinant) (N-His) (STJP007693)
SKU: STJP007693
Availability: InStock

Human MGRN1 protein (Recombinant) (N-His) (STJP007693)

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STJP007693

$443.48 - $1,940.63

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Host:	E. coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human MGRN1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Function	E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling.
Protein Name	E3 Ubiquitin-Protein Ligase Mgrn1 Mahogunin Ring Finger Protein 1 Ring Finger Protein 156 Ring-Type E3 Ubiquitin Transferase Mgrn1
Database Links	Reactome: R-HSA-983168
Cellular Localisation	Early Endosome The Endosomal Localization Is Dependent On The Interaction With Tsg101 Isoform 1: Cytoplasm Cytosol Nucleus Translocation From The Cytosol To The Nucleus Is Seen Only In The Presence Of Mc1r And Mc4r But Not Tbxa2r Excluded From Nucleoli Isoform 2: Cytoplasm Isoform 3: Cytoplasm Cell Membrane Isoform 4: Cytoplasm
Alternative Protein Names	E3 Ubiquitin-Protein Ligase Mgrn1 protein Mahogunin Ring Finger Protein 1 protein Ring Finger Protein 156 protein Ring-Type E3 Ubiquitin Transferase Mgrn1 protein MGRN1 protein KIAA0544 protein RNF156 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP005172	Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172)	E. coli
STJP004723	Human WAS protein (Recombinant) (N-His) (STJP004723)	E. coli
STJP002980	Human KLHL20 protein (Recombinant) (N-His) (STJP002980)	HEK293 cells
STJP003027	Human CCL3L1 protein (Recombinant) (N-His) (STJP003027)	HEK293 cells
STJP003488	Human CFD protein (Recombinant) (N-His) (STJP003488)	E. coli

Human MGRN1 protein (Recombinant) (N-His) (STJP007693)

General Information