Human MEX3C protein (Recombinant) (N-His) (STJP016288)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MEX3C-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | MEX3C |
| Gene ID | 51320 |
| Uniprot ID | MEX3C_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys210-Asn397 |
Additional Info
| Function | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. |
| Protein Name | Rna-Binding E3 Ubiquitin-Protein Ligase Mex3cRing Finger And Kh Domain-Containing Protein 2Ring Finger Protein 194Ring-Type E3 Ubiquitin Transferase Mex3c |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusPredominantly Expressed In The Cytoplasm And Shuttles Between The Cytoplasm And The Nucleus Through The Crm1 Export PathwayMay Act As Suppressor Of Replication Stress And Chromosome Missegregation |
| Alternative Protein Names | Rna-Binding E3 Ubiquitin-Protein Ligase Mex3c proteinRing Finger And Kh Domain-Containing Protein 2 proteinRing Finger Protein 194 proteinRing-Type E3 Ubiquitin Transferase Mex3c proteinMEX3C proteinRKHD2 proteinRNF194 proteinBM-013 protein |
Information sourced from Uniprot.org