| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human MEN1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | MEN1 |
| Gene ID: | 4221 |
| Uniprot ID: | MEN1_HUMAN |
| Immunogen Region: | Ser224-Pro395 |
| Immunogen: | Homo sapiens (Human) |
| Function | Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. |
| Protein Name | Menin |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2173796Reactome: R-HSA-3769402Reactome: R-HSA-381426Reactome: R-HSA-5626467Reactome: R-HSA-8957275Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusConcentrated In Nuclear Body-Like StructuresRelocates To The Nuclear Matrix Upon Gamma Irradiation |
| Alternative Protein Names | Menin proteinMEN1 proteinSCG2 protein |
Information sourced from Uniprot.org