| Short Description : | Recombinant-Human MDH1-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | < 1 EU/µg as determined by LAL test. |
| Gene Symbol: | MDH1 |
| Gene ID: | 4190 |
| Uniprot ID: | MDHC_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Ser2-Ala334 |
| Function | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS). |
| Protein Name | Malate Dehydrogenase - CytoplasmicAromatic Alpha-Keto Acid ReductaseKarCytosolic Malate Dehydrogenase |
| Database Links | Reactome: R-HSA-9856872 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Protein Names | Malate Dehydrogenase - Cytoplasmic proteinAromatic Alpha-Keto Acid Reductase proteinKar proteinCytosolic Malate Dehydrogenase proteinMDH1 proteinMDHA protein |
Information sourced from Uniprot.org
