| Tissue Specificity | |
| Post Translational Modifications | ISGylated. Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation. |
| Function | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS). |
| Protein Name | Malate Dehydrogenase - CytoplasmicAromatic Alpha-Keto Acid ReductaseKarCytosolic Malate Dehydrogenase |
| Database Links | Reactome: R-HSA-9856872 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative ELISA Names | Malate Dehydrogenase - Cytoplasmic ELISA kitAromatic Alpha-Keto Acid Reductase ELISA kitKar ELISA kitCytosolic Malate Dehydrogenase ELISA kitMDH1 ELISA kitMDHA ELISA kit |
| output | |
Information sourced from Uniprot.org