| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 6.6pg/mL |
| Detection Limit: | 15.6-1000pg/mL |
| Short Description : | This MCP1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | CCL2 |
| Gene ID: | 6347 |
| Uniprot ID: | CCL2_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed in monocytes. |
| Post Translational Modifications | Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. N-Glycosylated. |
| Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. |
| Protein Name | C-C Motif Chemokine 2 Hc11 Monocyte Chemoattractant Protein 1 Monocyte Chemotactic And Activating Factor Mcaf Monocyte Chemotactic Protein 1 Mcp-1 Monocyte Secretory Protein Je Small-Inducible Cytokine A2 |
| Database Links | Reactome: R-HSA-380108 Reactome: R-HSA-380994 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-9818026 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | C-C Motif Chemokine 2 ELISA kit Hc11 ELISA kit Monocyte Chemoattractant Protein 1 ELISA kit Monocyte Chemotactic And Activating Factor ELISA kit Mcaf ELISA kit Monocyte Chemotactic Protein 1 ELISA kit Mcp-1 ELISA kit Monocyte Secretory Protein Je ELISA kit Small-Inducible Cytokine A2 ELISA kit CCL2 ELISA kit MCP1 ELISA kit SCYA2 ELISA kit |
| output |
Information sourced from Uniprot.org