| Tissue Specificity | Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed in monocytes. |
| Post Translational Modifications | Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. N-Glycosylated. |
| Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. |
| Protein Name | C-C Motif Chemokine 2Hc11Monocyte Chemoattractant Protein 1Monocyte Chemotactic And Activating FactorMcafMonocyte Chemotactic Protein 1Mcp-1Monocyte Secretory Protein JeSmall-Inducible Cytokine A2 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-380994Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-9818026 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | C-C Motif Chemokine 2 ELISA kitHc11 ELISA kitMonocyte Chemoattractant Protein 1 ELISA kitMonocyte Chemotactic And Activating Factor ELISA kitMcaf ELISA kitMonocyte Chemotactic Protein 1 ELISA kitMcp-1 ELISA kitMonocyte Secretory Protein Je ELISA kitSmall-Inducible Cytokine A2 ELISA kitCCL2 ELISA kitMCP1 ELISA kitSCYA2 ELISA kit |
| output | |
Information sourced from Uniprot.org
