Human MCC protein (Recombinant) (N-GST & C-His) (STJP008832)

SKU:
STJP008832
£328.50 - £1,437.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MCC-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MCC
Gene ID: 4163
Uniprot ID: CRCM_HUMAN
Immunogen Region: Leu224-Ser294
Immunogen: Homo sapiens (Human)
Function Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity.
Protein Name Colorectal Mutant Cancer Protein
Protein Mcc
Cellular Localisation Cell Membrane
Cell Projection
Lamellipodium
Nucleus
Cytoplasm
Colocalizes With Actin At The Leading Edge Of Polarized Cells
Alternative Protein Names Colorectal Mutant Cancer Protein protein
Protein Mcc protein
MCC protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP011289 Human SOX9, N-GST & C-His protein (Recombinant) (N-GST & C-His) (STJP011289) E. coli
STJP009619 Human WAS protein (Recombinant) (N-GST & C-His) (STJP009619) E. coli
STJP010886 Human MCC protein (Recombinant) (N-His) (STJP010886) E. coli
STJP007410 Human MYL3 protein (Recombinant) (N-GST & C-His) (STJP007410) E. coli
STJP007465 Human FXYD1 protein (Recombinant) (N-GST & C-His) (STJP007465) E. coli

Related Products

!