| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.105ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description : | This MARCKSL1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | MARCKSL1 |
| Gene ID: | 65108 |
| Uniprot ID: | MRP_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Phosphorylated. Phosphorylation at Ser-120 and Thr-178 is non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8. May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin. |
| Function | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. |
| Protein Name | Marcks-Related Protein Marcks-Like Protein 1 Macrophage Myristoylated Alanine-Rich C Kinase Substrate Mac-Marcks Macmarcks |
| Database Links | |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Membrane Lipid-Anchor Associates With The Membrane Via The Insertion Of The N-Terminal N-Myristoyl Chain And The Partial Insertion Of The Effector Domain Association Of The Effector Domain With Membranes May Be Regulated By Ca(2+)/Calmodulin Colocalizes With F-Actin At The Leading Edge Of Migrating Cells In Prostate Cancers Shows Strong Expression At Apical And/Or Basal Regions Of The Cell And Also Has Weak Cytoplasmic Expression |
| Alternative ELISA Names | Marcks-Related Protein ELISA kit Marcks-Like Protein 1 ELISA kit Macrophage Myristoylated Alanine-Rich C Kinase Substrate ELISA kit Mac-Marcks ELISA kit Macmarcks ELISA kit MARCKSL1 ELISA kit MLP ELISA kit MRP ELISA kit |
| output |
Information sourced from Uniprot.org