Human MAP3K14 protein (Recombinant) (N-His) (STJP011246)

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STJP011246
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MAP3K14-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MAP3K14
Gene ID: 9020
Uniprot ID: M3K14_HUMAN
Immunogen Region: Ser332-Ser663
Immunogen: Homo sapiens (Human)
Post Translational Modifications Autophosphorylated. Phosphorylation at Thr-559 is required to activate its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization. Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.
Function Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway. Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response. Could act in a receptor-selective manner.
Protein Name Mitogen-Activated Protein Kinase Kinase Kinase 14
Nf-Kappa-Beta-Inducing Kinase
Hsnik
Serine/Threonine-Protein Kinase Nik
Database Links Reactome: R-HSA-389357
Reactome: R-HSA-5607761
Reactome: R-HSA-5668541
Reactome: R-HSA-5676590
Reactome: R-HSA-5676594
Cellular Localisation Cytoplasm
Alternative Protein Names Mitogen-Activated Protein Kinase Kinase Kinase 14 protein
Nf-Kappa-Beta-Inducing Kinase protein
Hsnik protein
Serine/Threonine-Protein Kinase Nik protein
MAP3K14 protein
NIK protein

Information sourced from Uniprot.org