| Post Translational Modifications | Autophosphorylated. Phosphorylation at Thr-559 is required to activate its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization. Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it. |
| Function | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway. Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response. Could act in a receptor-selective manner. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 14Nf-Kappa-Beta-Inducing KinaseHsnikSerine/Threonine-Protein Kinase Nik |
| Database Links | Reactome: R-HSA-389357Reactome: R-HSA-5607761Reactome: R-HSA-5668541Reactome: R-HSA-5676590Reactome: R-HSA-5676594 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Mitogen-Activated Protein Kinase Kinase Kinase 14 proteinNf-Kappa-Beta-Inducing Kinase proteinHsnik proteinSerine/Threonine-Protein Kinase Nik proteinMAP3K14 proteinNIK protein |
Information sourced from Uniprot.org
