| Tissue Specificity | Highly expressed in skeletal muscle. Also expressed in heart and brain. |
| Post Translational Modifications | Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2. Sumoylation at Lys-14 is required for active transcriptional repression. |
| Function | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin gene expression when associated with NFE2L2. May be involved in signal transduction of extracellular H(+). |
| Protein Name | Transcription Factor MafgV-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog GHmaf |
| Database Links | Reactome: R-HSA-9759194Reactome: R-HSA-9818028Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Transcription Factor Mafg proteinV-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog G proteinHmaf proteinMAFG protein |
Information sourced from Uniprot.org
