| Function | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. |
| Protein Name | Mitotic Spindle Assembly Checkpoint Protein Mad2aHsmad2Mitotic Arrest Deficient 2-Like Protein 1Mad2-Like Protein 1 |
| Database Links | Reactome: R-HSA-141405Reactome: R-HSA-141430Reactome: R-HSA-141444Reactome: R-HSA-174184Reactome: R-HSA-176409Reactome: R-HSA-179409Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreCytoplasmCytoskeletonSpindle PoleRecruited By Mad1l1 To Unattached Kinetochores (Probable)Recruited To The Nuclear Pore Complex By Tpr During InterphaseRecruited To Kinetochores In Late Prometaphase After Bub1CenpfBub1b And CenpeKinetochore Association Requires The Presence Of Nek2Kinetochore Association Is Repressed By UbdSequestered To The Cytoplasm Upon Interaction With Isoform 3 Of Mad1l1 |
| Alternative Protein Names | Mitotic Spindle Assembly Checkpoint Protein Mad2a proteinHsmad2 proteinMitotic Arrest Deficient 2-Like Protein 1 proteinMad2-Like Protein 1 proteinMAD2L1 proteinMAD2 protein |
Information sourced from Uniprot.org
