| Post Translational Modifications | Phosphorylated.by BUB1. Become hyperphosphorylated in late S through M phases or after mitotic spindle damage. Phosphorylated.by TTK. |
| Function | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling. Isoform 3: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. |
| Protein Name | Mitotic Spindle Assembly Checkpoint Protein Mad1Mitotic Arrest Deficient 1-Like Protein 1Mad1-Like Protein 1Mitotic Checkpoint Mad1 Protein HomologHsmad1Hmad1Tax-Binding Protein 181 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreNucleus EnvelopeCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleSpindle PoleCo-Localizes With Tpr At The Nucleus Envelope During Interphase And Throughout The Cell CycleFrom The Beginning To The End Of MitosisIt Is Seen To Move From A Diffusely Nuclear Distribution To The CentrosomeTo The Spindle Midzone And Finally To The MidbodyLocalizes To Kinetochores During PrometaphaseDoes Not Localize To Kinetochores During MetaphaseColocalizes With Nek2 At The KinetochoreColocalizes With Ik At Spindle Poles During Metaphase And AnaphaseIsoform 3: Cytoplasm |
| Alternative Protein Names | Mitotic Spindle Assembly Checkpoint Protein Mad1 proteinMitotic Arrest Deficient 1-Like Protein 1 proteinMad1-Like Protein 1 proteinMitotic Checkpoint Mad1 Protein Homolog proteinHsmad1 proteinHmad1 proteinTax-Binding Protein 181 proteinMAD1L1 proteinMAD1 proteinTXBP181 protein |
Information sourced from Uniprot.org
