| Function | GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus. In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E. Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape. |
| Protein Name | Lymphocyte Antigen 6eLy-6eRetinoic Acid-Induced Gene E ProteinRig-EStem Cell Antigen 2Sca-2Thymic Shared Antigen 1Tsa-1 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Protein Names | Lymphocyte Antigen 6e proteinLy-6e proteinRetinoic Acid-Induced Gene E Protein proteinRig-E proteinStem Cell Antigen 2 proteinSca-2 proteinThymic Shared Antigen 1 proteinTsa-1 proteinLY6E protein9804 proteinRIGE proteinSCA2 proteinTSA1 protein |
Information sourced from Uniprot.org
