Human LRRFIP1 protein (Recombinant) (N-His) (STJP005531)

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STJP005531
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Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LRRFIP1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: LRRFIP1
Gene ID: 9208
Uniprot ID: LRRF1_HUMAN
Immunogen Region: Asp615-Ser735
Immunogen: Homo sapiens (Human)
Function Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Protein Name Leucine-Rich Repeat Flightless-Interacting Protein 1
Lrr Flii-Interacting Protein 1
Gc-Binding Factor 2
Tar Rna-Interacting Protein
Database Links Reactome: R-HSA-1839117
Reactome: R-HSA-3134973
Reactome: R-HSA-5655302
Cellular Localisation Nucleus
Cytoplasm
Alternative Protein Names Leucine-Rich Repeat Flightless-Interacting Protein 1 protein
Lrr Flii-Interacting Protein 1 protein
Gc-Binding Factor 2 protein
Tar Rna-Interacting Protein protein
LRRFIP1 protein
GCF2 protein
TRIP protein

Information sourced from Uniprot.org

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