| Short Description : | Recombinant-Human LRRC4-C-His protein was developed in hek293 cells using the region Ala39-Lys527. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1.0 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | LRRC4 |
| Gene ID: | 64101 |
| Uniprot ID: | LRRC4_HUMAN |
| Immunogen: | Recombinant Human LRRC4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala39-Lys527) of human LRRC4 (Accession #NP_071426.1.) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Ala39-Lys527 |
| Immunogen Sequence: | ASAGPQNCPSVCSCSNQFSK VVCTRRGLSEVPQGIPSNTR YLNLMENNIQMIQADTFRHL HHLEVLQLGRNSIRQIEVGA FNGLASLNTLELFDNWLTVI PSGAFEYLSKLRELWLRNNP IESIPSYAFNRVPSLMRLDL GELKKLEYISEGAFEGLFNL KYLNLGMCNIKDMPNLTPLV GLEELEMSGNHFPEIRPGSF HGLSSLKKLWVMNSQVSLIE RNAFDGLASLVELNLAHNN |
| Tissue Specificity | Specifically expressed in brain. |
| Post Translational Modifications | N-glycosylated. |
| Function | Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma. |
| Protein Name | Leucine-Rich Repeat-Containing Protein 4Brain Tumor-Associated Protein BagNasopharyngeal Carcinoma-Associated Gene 14 ProteinNetrin-G2 LigandNgl-2 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinPostsynaptic Cell MembraneLrrc4 And Dlg4 Are Interdependent For Synaptic Localization |
| Alternative Protein Names | Leucine-Rich Repeat-Containing Protein 4 proteinBrain Tumor-Associated Protein Bag proteinNasopharyngeal Carcinoma-Associated Gene 14 Protein proteinNetrin-G2 Ligand proteinNgl-2 proteinLRRC4 proteinBAG proteinNAG14 proteinUNQ554 proteinPRO1111 protein |
Information sourced from Uniprot.org
