Human LRRC32/GARP protein (Recombinant) (C-Fc) (STJP013466)

Name: Human LRRC32/GARP protein (Recombinant) (C-Fc) (STJP013466)
SKU: STJP013466-100
Price: 575.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP013466-100

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Short Description	Recombinant-Human LRRC32/GARP-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Function	Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
Protein Name	Transforming Growth Factor Beta Activator Lrrc32 Garpin Glycoprotein A Repetitions Predominant Garp Leucine-Rich Repeat-Containing Protein 32
Database Links
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Surface
Alternative Protein Names	Transforming Growth Factor Beta Activator Lrrc32 protein Garpin protein Glycoprotein A Repetitions Predominant protein Garp protein Leucine-Rich Repeat-Containing Protein 32 protein LRRC32 protein D11S833E protein

Information sourced from Uniprot.org