Human LRP5 protein (Recombinant) (N-His) (STJP003344)

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STJP003344
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LRP5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: LRP5
Gene ID: 4041
Uniprot ID: LRP5_HUMAN
Immunogen Region: Cys1332-Leu1397
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through acting as a docking site for AXIN1.
Function Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development. Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis.
Protein Name Low-Density Lipoprotein Receptor-Related Protein 5
Lrp-5
Low-Density Lipoprotein Receptor-Related Protein 7
Lrp-7
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-4641262
Reactome: R-HSA-4641263
Reactome: R-HSA-5339717
Reactome: R-HSA-5340588
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum
Chaperoned To The Plasma Membrane By Mesd
Alternative Protein Names Low-Density Lipoprotein Receptor-Related Protein 5 protein
Lrp-5 protein
Low-Density Lipoprotein Receptor-Related Protein 7 protein
Lrp-7 protein
LRP5 protein
LR3 protein
LRP7 protein

Information sourced from Uniprot.org