| Tissue Specificity | Expressed in brain, testis, kidney, placenta and liver. |
| Function | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. |
| Protein Name | Protein Lin-7 Homolog ALin-7aHlin-7Mammalian Lin-Seven Protein 1Mals-1Tax Interaction Protein 33Tip-33Vertebrate Lin-7 Homolog 1Veli-1 |
| Database Links | Reactome: R-HSA-212676Reactome: R-HSA-6794361Reactome: R-HSA-9609736 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinBasolateral Cell MembraneCell JunctionPostsynaptic Density MembraneTight JunctionMainly Basolateral In Renal Epithelial Cells |
| Alternative Protein Names | Protein Lin-7 Homolog A proteinLin-7a proteinHlin-7 proteinMammalian Lin-Seven Protein 1 proteinMals-1 proteinTax Interaction Protein 33 proteinTip-33 proteinVertebrate Lin-7 Homolog 1 proteinVeli-1 proteinLIN7A proteinMALS1 proteinVELI1 protein |
Information sourced from Uniprot.org
