Human LGI1 protein (Recombinant) (N-His) (STJP010338)

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STJP010338
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LGI1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: LGI1
Gene ID: 9211
Uniprot ID: LGI1_HUMAN
Immunogen Region: Gly34-Ala557
Immunogen: Homo sapiens (Human)
Post Translational Modifications Glycosylated.
Function Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
Protein Name Leucine-Rich Glioma-Inactivated Protein 1
Epitempin-1
Database Links Reactome: R-HSA-5682910
Cellular Localisation Secreted
Synapse
Cytoplasm
Isoform 1: Golgi Apparatus
Isoform 2: Endoplasmic Reticulum
Alternative Protein Names Leucine-Rich Glioma-Inactivated Protein 1 protein
Epitempin-1 protein
LGI1 protein
EPT protein
UNQ775 protein
PRO1569 protein

Information sourced from Uniprot.org

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