Human LEPR (Leptin Receptor) Antibody Pair (STJAP00213)

SKU:
STJAP00213-50

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Host: Rabbit/Rabbit
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: This LEPR antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality: Polyclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A & Antigen Affinity.
Detection Purification: Protein A & Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: LEPR
Gene ID: 3953
Uniprot ID: LEPR_HUMAN
Immunogen: Capture immunogen: Recombinant Human LEPR protein.
Detection Immunogen: Recombinant Human LEPR protein.
Post Translational Modifications On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Phosphorylation of Tyr-1079 has a more accessory role.
Function Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production. Isoform A: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3. Isoform E: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.
Protein Name Leptin Receptor
Lep-R
Hub219
Ob Receptor
Ob-R
Cd Antigen Cd295
Database Links Reactome: R-HSA-2586552 P48357-1
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Basolateral Cell Membrane
Isoform E: Secreted
Alternative Antibody Pair Names Leptin Receptor antibody pair
Lep-R antibody pair
Hub219 antibody pair
Ob Receptor antibody pair
Ob-R antibody pair
Cd Antigen Cd295 antibody pair
LEPR antibody pair
DB antibody pair
OBR antibody pair

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance