Human LCAT protein (Recombinant) (N-His) (STJP003656)

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STJP003656
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LCAT-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: LCAT
Gene ID: 3931
Uniprot ID: LCAT_HUMAN
Immunogen Region: Phe25-Glu440
Immunogen: Homo sapiens (Human)
Post Translational Modifications O- and N-glycosylated. O-glycosylation on Thr-431 and Ser-433 consists of sialylated galactose beta 1-->3N-acetylgalactosamine structures. N-glycosylated sites contain sialylated triantennary and/or biantennary complex structures.
Function Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms. Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF. Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters.
Protein Name Phosphatidylcholine-Sterol Acyltransferase
1-Alkyl-2-Acetylglycerophosphocholine Esterase
Lecithin-Cholesterol Acyltransferase
Phospholipid-Cholesterol Acyltransferase
Platelet-Activating Factor Acetylhydrolase
Paf Acetylhydrolase
Database Links Reactome: R-HSA-8964058
Cellular Localisation Secreted
Secreted Into Blood Plasma
Produced In Astrocytes And Secreted Into Cerebral Spinal Fluid (Csf)
Alternative Protein Names Phosphatidylcholine-Sterol Acyltransferase protein
1-Alkyl-2-Acetylglycerophosphocholine Esterase protein
Lecithin-Cholesterol Acyltransferase protein
Phospholipid-Cholesterol Acyltransferase protein
Platelet-Activating Factor Acetylhydrolase protein
Paf Acetylhydrolase protein
LCAT protein

Information sourced from Uniprot.org

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