| Post Translational Modifications | The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, LC3-I. The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, LC3-II. During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid. ATG4 proteins also mediate the delipidation of PE-conjugated forms. In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non-canonical autophagy. |
| Function | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. |
| Protein Name | Microtubule-Associated Protein 1 Light Chain 3 Beta 2Microtubule-Associated Proteins 1a/1b Light Chain 3 Beta 2Microtubule-Associated Proteins 1a/1b Light Chain 3b-LikeMap1a/Map1b Lc3 B-LikeMap1a/Map1b Light Chain 3 B-Like |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleAutophagosome MembraneLipid-AnchorEndomembrane SystemCytoplasmCytoskeleton |
| Alternative Protein Names | Microtubule-Associated Protein 1 Light Chain 3 Beta 2 proteinMicrotubule-Associated Proteins 1a/1b Light Chain 3 Beta 2 proteinMicrotubule-Associated Proteins 1a/1b Light Chain 3b-Like proteinMap1a/Map1b Lc3 B-Like proteinMap1a/Map1b Light Chain 3 B-Like proteinMAP1LC3B2 protein |
Information sourced from Uniprot.org
