| Post Translational Modifications | Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation.which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes. Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation. 'Lys-63'-linked ubiquitinated by TRAF6. |
| Function | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. |
| Protein Name | Linker For Activation Of T-Cells Family Member 136 Kda Phosphotyrosine Adapter ProteinPp36P36-38 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-202433Reactome: R-HSA-2424491 O43561-2Reactome: R-HSA-2454202 O43561-2Reactome: R-HSA-2871796 O43561-2Reactome: R-HSA-2871809 O43561-2Reactome: R-HSA-5673001 O43561-2 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinPresent In Lipid Rafts |
| Alternative Protein Names | Linker For Activation Of T-Cells Family Member 1 protein36 Kda Phosphotyrosine Adapter Protein proteinPp36 proteinP36-38 proteinLAT protein |
Information sourced from Uniprot.org
