| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes. |
| Protein Name | Laminin Subunit Alpha-3Epiligrin 170 Kda SubunitE170Epiligrin Subunit AlphaKalinin Subunit AlphaLaminin-5 Subunit AlphaLaminin-6 Subunit AlphaLaminin-7 Subunit AlphaNicein Subunit Alpha |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-2022090Reactome: R-HSA-2214320Reactome: R-HSA-3000157Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-446107Reactome: R-HSA-8874081Reactome: R-HSA-9913351 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMajor Component |
| Alternative Protein Names | Laminin Subunit Alpha-3 proteinEpiligrin 170 Kda Subunit proteinE170 proteinEpiligrin Subunit Alpha proteinKalinin Subunit Alpha proteinLaminin-5 Subunit Alpha proteinLaminin-6 Subunit Alpha proteinLaminin-7 Subunit Alpha proteinNicein Subunit Alpha proteinLAMA3 proteinLAMNA protein |
Information sourced from Uniprot.org