| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 6.1pg/mL |
| Detection Limit: | 15.6-1000pg/mL |
| Short Description : | This LAMa3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | LAMA3 |
| Gene ID: | 3909 |
| Uniprot ID: | LAMA3_HUMAN |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Skin.respiratory, urinary, and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane, and epithelial cell tongue that migrates into a wound bed. A differential and focal expression of the subunit alpha-3 is observed in the CNS. |
| Post Translational Modifications | |
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes. |
| Protein Name | Laminin Subunit Alpha-3 Epiligrin 170 Kda Subunit E170 Epiligrin Subunit Alpha Kalinin Subunit Alpha Laminin-5 Subunit Alpha Laminin-6 Subunit Alpha Laminin-7 Subunit Alpha Nicein Subunit Alpha |
| Database Links | Reactome: R-HSA-1474228 Reactome: R-HSA-2022090 Reactome: R-HSA-2214320 Reactome: R-HSA-3000157 Reactome: R-HSA-3000171 Reactome: R-HSA-3000178 Reactome: R-HSA-446107 Reactome: R-HSA-8874081 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix Basement Membrane Major Component |
| Alternative ELISA Names | Laminin Subunit Alpha-3 ELISA kit Epiligrin 170 Kda Subunit ELISA kit E170 ELISA kit Epiligrin Subunit Alpha ELISA kit Kalinin Subunit Alpha ELISA kit Laminin-5 Subunit Alpha ELISA kit Laminin-6 Subunit Alpha ELISA kit Laminin-7 Subunit Alpha ELISA kit Nicein Subunit Alpha ELISA kit LAMA3 ELISA kit LAMNA ELISA kit |
| output |
Information sourced from Uniprot.org