• Biotinylated Human LAIR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human LAIR1 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Biotinylated Human LAIR1, His Tag at 0. 5 Mu g/ml (100 Mu l/Well) on streptavidin (5 Mu g/ml) precoated plate. Dose response curve for Anti-LAIR1 Antibody, hFc Tag with the EC50 of 7. 3ng/ml determined by ELISA.

Human LAIR1/CD305 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001671)

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STJP001671

£618.50 - £1,909.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human LAIR1/CD305-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: LAIR1
Gene ID: 3903
Uniprot ID: LAIR1_HUMAN
Immunogen Region: Gln22-His163
Immunogen: DNA sequence encoding Human LAIR1/CD305 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK. N-glycosylated.
Function Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Protein Name Leukocyte-Associated Immunoglobulin-Like Receptor 1
Lair-1
Hlair1
Cd Antigen Cd305
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Leukocyte-Associated Immunoglobulin-Like Receptor 1 protein
Lair-1 protein
Hlair1 protein
Cd Antigen Cd305 protein
LAIR1 protein
CD305 protein

Information sourced from Uniprot.org

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