| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.059ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description : | This KRT2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | KRT2 |
| Gene ID: | 3849 |
| Uniprot ID: | K22E_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization. |
| Post Translational Modifications | |
| Function | Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Required for maintenance of corneocytes and keratin filaments in suprabasal keratinocytes in the epidermis of the ear, potentially via moderation of expression and localization of keratins and their partner proteins. Plays a role in the establishment of the epidermal barrier on plantar skin. |
| Protein Name | Keratin - Type Ii Cytoskeletal 2 Epidermal Cytokeratin-2e Ck-2e Epithelial Keratin-2e Keratin-2 Epidermis Keratin-2e K2e Type-Ii Keratin Kb2 |
| Database Links | Reactome: R-HSA-6805567 Reactome: R-HSA-6809371 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Keratin - Type Ii Cytoskeletal 2 Epidermal ELISA kit Cytokeratin-2e ELISA kit Ck-2e ELISA kit Epithelial Keratin-2e ELISA kit Keratin-2 Epidermis ELISA kit Keratin-2e ELISA kit K2e ELISA kit Type-Ii Keratin Kb2 ELISA kit KRT2 ELISA kit KRT2A ELISA kit KRT2E ELISA kit |
| output |
Information sourced from Uniprot.org