Human KPNA2 protein (Recombinant) (N-His) (STJP004894)

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STJP004894
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human KPNA2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: KPNA2
Gene ID: 3838
Uniprot ID: IMA1_HUMAN
Immunogen Region: Ala157-Gln412
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated. Deubiquitinated by USP22.leading to stabilization and increased activity.
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import.acts redundantly with KPNA1 and Transportin-1/TNPO1.
Protein Name Importin Subunit Alpha-1
Karyopherin Subunit Alpha-2
Rag Cohort Protein 1
Srp1-Alpha
Database Links Reactome: R-HSA-111932
Reactome: R-HSA-1169408
Reactome: R-HSA-168276
Reactome: R-HSA-442729
Reactome: R-HSA-5693548
Reactome: R-HSA-9018519
Reactome: R-HSA-9692916
Reactome: R-HSA-9705671
Cellular Localisation Cytoplasm
Nucleus
Endoplasmic Reticulum Membrane
Golgi Apparatus Membrane
(Microbial Infection) Retained In Er/Golgi Membranes Upon Interaction With Sars-Cov Virus Orf6 Protein
Alternative Protein Names Importin Subunit Alpha-1 protein
Karyopherin Subunit Alpha-2 protein
Rag Cohort Protein 1 protein
Srp1-Alpha protein
KPNA2 protein
RCH1 protein
SRP1 protein

Information sourced from Uniprot.org