| Post Translational Modifications | Ubiquitinated. Deubiquitinated by USP22.leading to stabilization and increased activity. |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import.acts redundantly with KPNA1 and Transportin-1/TNPO1. |
| Protein Name | Importin Subunit Alpha-1Karyopherin Subunit Alpha-2Rag Cohort Protein 1Srp1-Alpha |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-1169408Reactome: R-HSA-168276Reactome: R-HSA-442729Reactome: R-HSA-5693548Reactome: R-HSA-9018519Reactome: R-HSA-9692916Reactome: R-HSA-9705671 |
| Cellular Localisation | CytoplasmNucleusEndoplasmic Reticulum MembraneGolgi Apparatus Membrane(Microbial Infection) Retained In Er/Golgi Membranes Upon Interaction With Sars-Cov Virus Orf6 Protein |
| Alternative Protein Names | Importin Subunit Alpha-1 proteinKaryopherin Subunit Alpha-2 proteinRag Cohort Protein 1 proteinSrp1-Alpha proteinKPNA2 proteinRCH1 proteinSRP1 protein |
Information sourced from Uniprot.org
