Human KLRF1 protein (Recombinant) (N-His) (STJP013756)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KLRF1-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | KLRF1 |
| Gene ID | 51348 |
| Uniprot ID | KLRF1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val66-Tyr231 |
Additional Info
| Post Translational Modifications | Phosphorylated on Tyr-7.this phosphorylation is required for NKp80/KLRF1-mediated cytotoxicity. |
| Function | Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases. |
| Protein Name | Killer Cell Lectin-Like Receptor Subfamily F Member 1Lectin-Like Receptor F1Activating Coreceptor Nkp80C-Type Lectin Domain Family 5 Member C |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Killer Cell Lectin-Like Receptor Subfamily F Member 1 proteinLectin-Like Receptor F1 proteinActivating Coreceptor Nkp80 proteinC-Type Lectin Domain Family 5 Member C proteinKLRF1 proteinCLEC5C proteinML protein |
Information sourced from Uniprot.org