| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Human KLK1-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Gene Symbol: | KLK1 |
| Gene ID: | 3816 |
| Uniprot ID: | KLK1_HUMAN |
| Immunogen Region: | Ile25-Ser262 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located. |
| Function | Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. (Microbial infection) Cleaves Neisseria meningitidis NHBA in saliva.Neisseria is an obligate commensal of the nasopharyngeal mucosa. |
| Protein Name | Kallikrein-1Kidney/Pancreas/Salivary Gland KallikreinTissue Kallikrein |
| Database Links | Reactome: R-HSA-381426 |
| Alternative Protein Names | Kallikrein-1 proteinKidney/Pancreas/Salivary Gland Kallikrein proteinTissue Kallikrein proteinKLK1 protein |
Information sourced from Uniprot.org
