| Tissue Specificity | Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct. |
| Post Translational Modifications | Phosphorylation at Ser-542 and Ser-931 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B. |
| Function | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Plays a role in cognition and memory performance. Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning. |
| Protein Name | Protein KibraHbeag-Binding Protein 3Kidney And Brain ProteinKibraWw Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-2028269Reactome: R-HSA-9013508 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusCell ProjectionRuffle MembraneCytosolColocalizes With Prkcz In The Perinuclear Region |
| Alternative Protein Names | Protein Kibra proteinHbeag-Binding Protein 3 proteinKidney And Brain Protein proteinKibra proteinWw Domain-Containing Protein 1 proteinWWC1 proteinKIAA0869 proteinKIBRA protein |
Information sourced from Uniprot.org
