| Post Translational Modifications | Palmitoylated. Palmitoylation enhances association with the plasma membrane. Proteolytically cleaved by caspase-3. Phosphorylation at Ser-63 inhibits cleavage by CASP3. |
| Function | Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception. Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. |
| Protein Name | CalsenilinA-Type Potassium Channel Modulatory Protein 3Dre-Antagonist ModulatorDreamKv Channel-Interacting Protein 3Kchip3 |
| Database Links | Reactome: R-HSA-5576894Reactome: R-HSA-9768777 |
| Cellular Localisation | CytoplasmCell MembraneLipid-AnchorEndoplasmic ReticulumGolgi ApparatusNucleusAlso Membrane-BoundAssociated With The Plasma MembraneIn The Presence Of Psen2 Associated With The Endoplasmic Reticulum And GolgiThe Sumoylated Form Is Present Only In The Nucleus |
| Alternative Protein Names | Calsenilin proteinA-Type Potassium Channel Modulatory Protein 3 proteinDre-Antagonist Modulator proteinDream proteinKv Channel-Interacting Protein 3 proteinKchip3 proteinKCNIP3 proteinCSEN proteinDREAM proteinKCHIP3 protein |
Information sourced from Uniprot.org
