Human KCC2 (Potassium Chloride Cotransporters 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016521)

Human KCC2 (Potassium Chloride Cotransporters 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016521)

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STJE0016521
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.107ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This KCC2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: SLC12A5
Gene ID: 57468
Uniprot ID: S12A5_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Brain specific. Detected in neuronal cells.
Post Translational Modifications Phosphorylated at Thr-929 and Thr-1030 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), inhibiting the potassium-chloride cotransport activity.
Function Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.
Protein Name Solute Carrier Family 12 Member 5
Electroneutral Potassium-Chloride Cotransporter 2
K-Cl Cotransporter 2
Hkcc2
Neuronal K-Cl Cotransporter
Database Links Reactome: R-HSA-426117
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Dendrite
Detected On Dendrites
But Not On Axons Of Spinal Cord Neurons And At Gphn-Positive Inhibitory Synapses
Alternative ELISA Names Solute Carrier Family 12 Member 5 ELISA kit
Electroneutral Potassium-Chloride Cotransporter 2 ELISA kit
K-Cl Cotransporter 2 ELISA kit
Hkcc2 ELISA kit
Neuronal K-Cl Cotransporter ELISA kit
SLC12A5 ELISA kit
KCC2 ELISA kit
KIAA1176 ELISA kit
output

Information sourced from Uniprot.org

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