Human Kallikrein 7/KLK7 protein (Recombinant) (His-Tag) (STJP017845)

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STJP017845
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Kallikrein 7/KLK7-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2M uREA, 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: KLK7
Gene ID: 5650
Uniprot ID: KLK7_HUMAN
Immunogen Region: 30-253aa
Accession Number: NP_005037
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMIIDGA PCARGSHPWQ VALLSGNQLH CGGVLVNERW VLTAAHCKMN EYTVHLGSDT LGDRRAQRIK ASKSFRHPGY STQTHVNDLM LVKLNSQARL SSMVKKVRLP SRCEPPGTTC TVSGWGTTTS PDVTFPSDLM CVDVKLISPQ DCTKVYKDLL ENSMLCAGIP DSKKNACNGD SGGPLVCRGT LQGLVSWGTF PCGQPNDP
Tissue Specificity Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).
Function May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
Protein Name Kallikrein-7
Hk7
Serine Protease 6
Stratum Corneum Chymotryptic Enzyme
Hscce
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-9725554
Cellular Localisation Secreted
In Ovarian Carcinoma
Secreted And Also Observed At The Apical Membrane And In Cytoplasm At The Invasive Front
Alternative Protein Names Kallikrein-7 protein
Hk7 protein
Serine Protease 6 protein
Stratum Corneum Chymotryptic Enzyme protein
Hscce protein
KLK7 protein
PRSS6 protein
SCCE protein

Information sourced from Uniprot.org

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