Human JAM1 (Junctional Adhesion Molecule 1) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016505)

Human JAM1 (Junctional Adhesion Molecule 1) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016505)

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STJE0016505
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.133ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This JAM1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: F11R
Gene ID: 50848
Uniprot ID: JAM1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in endothelium, epithelium and leukocytes (at protein level).
Post Translational Modifications N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions.
Function Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
Protein Name Junctional Adhesion Molecule A
Jam-A
Junctional Adhesion Molecule 1
Jam-1
Platelet F11 Receptor
Platelet Adhesion Molecule 1
Pam-1
Cd Antigen Cd321
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-2173791
Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Localized At Tight Junctions Of Both Epithelial And Endothelial Cells
Alternative ELISA Names Junctional Adhesion Molecule A ELISA kit
Jam-A ELISA kit
Junctional Adhesion Molecule 1 ELISA kit
Jam-1 ELISA kit
Platelet F11 Receptor ELISA kit
Platelet Adhesion Molecule 1 ELISA kit
Pam-1 ELISA kit
Cd Antigen Cd321 ELISA kit
F11R ELISA kit
JAM1 ELISA kit
JCAM ELISA kit
UNQ264 ELISA kit
PRO301 ELISA kit
output

Information sourced from Uniprot.org

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