Human JAM-A/F11R protein (Recombinant) (His-Tag) (STJP017666)

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STJP017666
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human JAM-A/F11R-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.15M NaCl, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: F11R
Gene ID: 50848
Uniprot ID: JAM1_HUMAN
Immunogen Region: 26-238aa
Accession Number: NP_058642
Immunogen: Human
Immunogen Sequence: LGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNA
Tissue Specificity Expressed in endothelium, epithelium and leukocytes (at protein level).
Post Translational Modifications N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions.
Function Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
Protein Name Junctional Adhesion Molecule A
Jam-A
Junctional Adhesion Molecule 1
Jam-1
Platelet F11 Receptor
Platelet Adhesion Molecule 1
Pam-1
Cd Antigen Cd321
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-2173791
Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Localized At Tight Junctions Of Both Epithelial And Endothelial Cells
Alternative Protein Names Junctional Adhesion Molecule A protein
Jam-A protein
Junctional Adhesion Molecule 1 protein
Jam-1 protein
Platelet F11 Receptor protein
Platelet Adhesion Molecule 1 protein
Pam-1 protein
Cd Antigen Cd321 protein
F11R protein
JAM1 protein
JCAM protein
UNQ264 protein
PRO301 protein

Information sourced from Uniprot.org

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