• Human JAM-A/F11R/CD321 protein (Recombinant) (C-His) (STJP001046)

Human JAM-A/F11R/CD321 protein (Recombinant) (C-His) (STJP001046)

SKU:
STJP001046

£105.50 - £248.50
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Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human JAM-A/F11R/CD321-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: F11R
Gene ID: 50848
Uniprot ID: JAM1_HUMAN
Immunogen: Recombinant Human JAM-A/F11R/CD321 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser28-Ala242) of human JAM-A (Accession #NP_058642.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Expressed in endothelium, epithelium and leukocytes (at protein level).
Post Translational Modifications N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions.
Function Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
Protein Name Junctional Adhesion Molecule A
Jam-A
Junctional Adhesion Molecule 1
Jam-1
Platelet F11 Receptor
Platelet Adhesion Molecule 1
Pam-1
Cd Antigen Cd321
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-2173791
Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Localized At Tight Junctions Of Both Epithelial And Endothelial Cells
Alternative Protein Names Junctional Adhesion Molecule A protein
Jam-A protein
Junctional Adhesion Molecule 1 protein
Jam-1 protein
Platelet F11 Receptor protein
Platelet Adhesion Molecule 1 protein
Pam-1 protein
Cd Antigen Cd321 protein
F11R protein
JAM1 protein
JCAM protein
UNQ264 protein
PRO301 protein

Information sourced from Uniprot.org

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