Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Human JAM-A/F11R/CD321-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
Gene Symbol: |
F11R |
Gene ID: |
50848 |
Uniprot ID: |
JAM1_HUMAN |
Immunogen: |
Recombinant Human JAM-A/F11R/CD321 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ser28-Ala242) of human JAM-A (Accession #NP_058642.1) fused with an Fc, 6×His tag at the C-terminus. |
Tissue Specificity | Expressed in endothelium, epithelium and leukocytes (at protein level). |
Post Translational Modifications | N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions. |
Function | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. |
Protein Name | Junctional Adhesion Molecule AJam-AJunctional Adhesion Molecule 1Jam-1Platelet F11 ReceptorPlatelet Adhesion Molecule 1Pam-1Cd Antigen Cd321 |
Database Links | Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-2173791Reactome: R-HSA-420029 |
Cellular Localisation | Cell JunctionTight JunctionCell MembraneSingle-Pass Type I Membrane ProteinLocalized At Tight Junctions Of Both Epithelial And Endothelial Cells |
Alternative Protein Names | Junctional Adhesion Molecule A proteinJam-A proteinJunctional Adhesion Molecule 1 proteinJam-1 proteinPlatelet F11 Receptor proteinPlatelet Adhesion Molecule 1 proteinPam-1 proteinCd Antigen Cd321 proteinF11R proteinJAM1 proteinJCAM proteinUNQ264 proteinPRO301 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance