| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human ITPRIPL1-N-His-KSI protein was developed from e. coli and has a target region of N-His-KSI. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | ITPRIPL1 |
| Gene ID: | 150771 |
| Uniprot ID: | IPIL1_HUMAN |
| Immunogen Region: | His25-Gly103 |
| Immunogen: | Homo sapiens (Human) |
| Function | Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx. |
| Protein Name | Inositol 1 -4 -5-Trisphosphate Receptor-Interacting Protein-Like 1 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Inositol 1 -4 -5-Trisphosphate Receptor-Interacting Protein-Like 1 proteinITPRIPL1 proteinKIAA1754L protein |
Information sourced from Uniprot.org