Human ITPA protein (Recombinant) (His-Tag) (STJP016779)

Name: Human ITPA protein (Recombinant) (His-Tag) (STJP016779)
SKU: STJP016779
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP016779

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Short Description	Recombinant-Human ITPA-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	ITPA
Gene ID	3704
Uniprot ID	ITPA_HUMAN
Accession Number	NP_258412
Immunogen	Human
Immunogen Region	1-194aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MMAASLVGKK IVFVTGNAKK LEEVVQILGD KFPCTLVAQK IDLPEYQGEP DEISIQKCQE AVRQVQGPVL VEDTCLCFNA LGGLPGPYIK WFLEKLKPEG LHQLLAGFED KSAYALCTFA LSTGDPSQPV RLFRGRTSGR IVAPRGCQDF GWDPCFQPDG YEQTYAEMPK AEKNAVSHRF RALLELQEYF GSLAA

Tissue Specificity	Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
Function	Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Protein Name	Inosine Triphosphate Pyrophosphatase Itpase Inosine Triphosphatase Non-Canonical Purine Ntp Pyrophosphatase Non-Standard Purine Ntp Pyrophosphatase Nucleoside-Triphosphate Diphosphatase Nucleoside-Triphosphate Pyrophosphatase Ntpase Putative Oncogene Protein Hlc14-06-P Xtp/Ditp Diphosphatase
Database Links	Reactome: R-HSA-74259 Reactome: R-HSA-9755088
Cellular Localisation	Cytoplasm
Alternative Protein Names	Inosine Triphosphate Pyrophosphatase protein Itpase protein Inosine Triphosphatase protein Non-Canonical Purine Ntp Pyrophosphatase protein Non-Standard Purine Ntp Pyrophosphatase protein Nucleoside-Triphosphate Diphosphatase protein Nucleoside-Triphosphate Pyrophosphatase protein Ntpase protein Putative Oncogene Protein Hlc14-06-P protein Xtp/Ditp Diphosphatase protein ITPA protein C20orf37 protein My049 protein OK protein SW-cl.9 protein

Information sourced from Uniprot.org