Tissue Specificity | Plasma. |
Post Translational Modifications | Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Phosphorylated by FAM20C in the extracellular medium. |
Function | May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. |
Protein Name | Inter-Alpha-Trypsin Inhibitor Heavy Chain H2Iti Heavy Chain H2Iti-Hc2Inter-Alpha-Inhibitor Heavy Chain 2Inter-Alpha-Trypsin Inhibitor Complex Component IiSerum-Derived Hyaluronan-Associated ProteinShap |
Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
Cellular Localisation | Secreted |
Alternative ELISA Names | Inter-Alpha-Trypsin Inhibitor Heavy Chain H2 ELISA kitIti Heavy Chain H2 ELISA kitIti-Hc2 ELISA kitInter-Alpha-Inhibitor Heavy Chain 2 ELISA kitInter-Alpha-Trypsin Inhibitor Complex Component Ii ELISA kitSerum-Derived Hyaluronan-Associated Protein ELISA kitShap ELISA kitITIH2 ELISA kitIGHEP2 ELISA kit |
output | |
Information sourced from Uniprot.org