Human IRF9 protein (Recombinant) (N-His) (STJP005116)

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STJP005116
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IRF9-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IRF9
Gene ID: 10379
Uniprot ID: IRF9_HUMAN
Immunogen Region: Met1-Val393
Immunogen: Homo sapiens (Human)
Function Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Protein Name Interferon Regulatory Factor 9
Irf-9
Ifn-Alpha-Responsive Transcription Factor Subunit
Isgf3 P48 Subunit
Interferon-Stimulated Gene Factor 3 Gamma
Isgf-3 Gamma
Transcriptional Regulator Isgf3 Subunit Gamma
Database Links Reactome: R-HSA-877300
Reactome: R-HSA-909733
Cellular Localisation Cytoplasm
Nucleus
Translocated Into The Nucleus Upon Activation By Ifn-Alpha/Beta
Alternative Protein Names Interferon Regulatory Factor 9 protein
Irf-9 protein
Ifn-Alpha-Responsive Transcription Factor Subunit protein
Isgf3 P48 Subunit protein
Interferon-Stimulated Gene Factor 3 Gamma protein
Isgf-3 Gamma protein
Transcriptional Regulator Isgf3 Subunit Gamma protein
IRF9 protein
ISGF3G protein

Information sourced from Uniprot.org

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