| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human IPP-3/PPP1R11-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% Glycerol, 1mM DTT |
| Concentration: | 0.25 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP1R11 |
| Gene ID: | 6992 |
| Uniprot ID: | PP1RB_HUMAN |
| Immunogen Region: | 1-126aa |
| Accession Number: | NP_068778 |
| Immunogen: | Human |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAEAGAG LSETVTETTV TVTTEPENRS LTIKLRKRKP EKKVEWTSDT VDNEHMGRRS SKCCCIYEKP RAFGESSTES DEEEEEGCGH THCVRGHRKG RRRATLGPTP TTPPQPPDPS QPPPGPMQH |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ppp1r11Hemochromatosis Candidate Gene V ProteinHcg VProtein Phosphatase 1 Regulatory Subunit 11Protein Phosphatase Inhibitor 3 |
| Database Links | |
| Cellular Localisation | |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Ppp1r11 proteinHemochromatosis Candidate Gene V Protein proteinHcg V proteinProtein Phosphatase 1 Regulatory Subunit 11 proteinProtein Phosphatase Inhibitor 3 proteinPPP1R11 proteinHCGV proteinTCTE5 protein |
Information sourced from Uniprot.org